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Fashion designer Charlie Brown is to undergo brain surgery on Tuesday following the detection of a small growth.

Surgeons recently discovered a cyst on her brain after Brown, one of the Australian fashion industry's most high-profile businesswomen, started complaining of headaches and general lethargy.

Her family declined to comment when contacted on Friday.

Husband and business partner Danny Avidan said: "Please understand, we are relieved by the news that it is not cancer, but we don't wish to discuss it further."

He declined to say which surgeon would be operating on his wife or at which hospital.

The dynamo behind brands Charlie Brown, lili and Princess Charlotte recently had a biopsy, which revealed the growth to be benign.

Brown's appearance at Mercedes Australian Fashion Week in May prompted talk that she may have been working too hard in the weeks preceding the event.

She appeared pale and close friends have since revealed she was suffering from exhaustion.

"She has been unable to shake the feeling of tiredness and has been feeling chronically unwell," one friend said.

It transpires that the designer has been nursing a nagging shoulder injury - "a cracked shoulder" for several months - and was struggling with the injury throughout Fashion Week. The injury prompted her to seek further professional advice and undergo a series of scans, one of which revealed the cyst on her brain.

Brown, a mother of three who converted to Judaism when she married, was relieved to have at last been given a positive diagnosis and was spending this weekend "observing the Sabbath, drawing strength from her family and praying for a successful outcome on Tuesday", a source close to her said.

"She is in the best of hands and has only her post-operative recovery to be focused on," the source said.

Brown had enjoyed a bumper year leading up to Fashion Week, where she once again won the battle for media exposure by featuring British fashion icon Jade Jagger on the catwalk.

Brown and Avidan recently opened a new boutique in Melbourne's thriving Chadstone and are poised to open her second boutique in central Melbourne.

Sources in Avidan's Discovery Group said the Charlie Brown label was set to announce sales of $20 million this year, a record for the label that was on the brink of liquidation only a few years ago.

Last week, Brown's husband confiscated her mobile phone and she was banned from her office to keep her from working and to encourage her to prepare for the surgery.

Friends said that, if it weren't for Brown's characteristic perseverance, the cyst would not have been detected and she'd still be unaware of its presence.

"She was determined to discover the root of her health problems so just kept having scans until she finally got the news," one said.

If all goes well, Brown will take a month off to recover before returning to work.

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